Molecular Hydrogen

• Supports a healthy inflammatory response for whole-body health*

• Helps protect against everyday environmental stressors*

• Ultra-small, neutrally-charged, and non-polar molecule easily travels through the body, supporting antioxidant activity and redox balance*

• Modulates inflammation to support normal, healthy organ function*

• Supports healthy energy levels and balances sympathetic nervous system activity*

 Antioxidant:

• Molecular Hydrogen neutralizes hydroxyl and peroxynitrite free radicals*

• Helps protect DNA and cellular proteins from oxidative damage*

• Activates Nrf2 pathway, enhancing the body’s production of important antioxidant and detoxifying enzymes*

• Clinically shown to help protect against radiation, improving taste, appetite, and quality of life*

• Helps protect cells of the immune and reproductive systems, heart, and gut against damage from radiation*

 Immune: 

• Molecular Hydrogen balances excessive immune response to support normal organ function*

• Clinically shown to help inhibit inflammation to support skin and joint health*

• Supports healthy immune response and inhibits cellular damage by modulating inflammation and oxidative stress*

• Supports improved outcomes in response to immune challenges*

 Brain:  

• Molecular Hydrogen enhances alertness and improves test-taking speed and response accuracy after sleep deprivation*

• Helps protect the brain in both acute and chronic challenges*

• Supports function of neurons involved in production of dopamine, an important neurotransmitter for mood, motivation, and motor control*

• Enhances mood, cognitive performance, and resilience in stressful settings*

• Clinically shown to help reduce psychological distress and support a healthy mood*

Metabolic/Cardiovascular Health:

• Molecular Hydrogen promotes healthy metabolic function*

• Supports healthy body composition*

• Supports already-healthy glucose metabolism*

• Helps maintain healthy cholesterol levels already within the normal range*

• Supports healthy ApoB levels and reduces markers of cholesterol oxidation*

• Supports healthy blood vessel function*

 Liver:

• Molecular Hydrogen supports liver metabolic health and reduces excessive liver fat*

• Helps protect the liver from oxidative damage*

• Promotes healthy liver glutathione and antioxidant enzyme levels*

 Athletic performance:

• Molecular Hydrogen enhances mitochondrial energy production and mitochondria biogenesis*

• Improves muscle recovery after intense physical activity*

• Enhances soft tissue recovery, improving joint range of motion*

• Attenuates exercise-induced increases in lactic acid*

• Enhances lung function, increasing VO2 max and time to exhaustion*

• Supports sustained exertion, improving peak power output and reducing fatigue*

1. Molecular hydrogen: a therapeutic antioxidant and beyond

Huang L. Molecular hydrogen: a therapeutic antioxidant and beyond. Medical Gas Research. 2016;6(4):219-222. doi:10.4103/2045-9912.196904.

2. Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

Ohta S. Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications. Current Pharmaceutical Design. 2011;17(22):2241-2252. doi:10.2174/138161211797052664.

3. A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.

Shen M, Zhang H, Yu C, Wang F, Sun X. A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine. Medical Gas Research. 2014;4:17. doi:10.1186/2045-9912-4-17.

4. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.

Shigeo Ohta, Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine, Pharmacology & Therapeutics, Volume 144, Issue 1, 2014, Pages 1-11, ISSN 0163-7258.

Credit for this list given to the Molecular Hydrogen Institute and Vital Reaction.

Hydrogen and Alzheimer's

https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Molecular-Hydrogen-Cognitive-Vitality-For-Researchers.pdf

bioaccent.org/articles/international-journal-of-alzheimers-and-neurological-disorders/alzheimers-neurological-003.pdf 

drsircus.com/hydrogen-medicine/anti-aging-anti-alzheimers-hydrogen-photobiomodulation-protocol/ 

Hydrogen and Parkinson's

https://www.hindawi.com/journals/pd/2011/307875/

Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease

https://www.jstage.jst.go.jp/article/jcbn/61/1/61_16-87/_article

2017, Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration

https://www.intechopen.com/online-first/78522

2021, ROS in Neurodegenerative Diseases: Implications in Pathogenesis and Treatment Strategies

https://pubmed.ncbi.nlm.nih.gov/31432604/

2019, Oxidative stress in the aging substantia nigra and the etiology of Parkinson’s disease

https://www.nature.com/articles/s41540-020-00150-w

2020, ROS networks: designs, aging, Parkinson’s disease and precision therapies

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4495335/

2015, Oxidative stress and Parkinson’s disease

https://www.mdpi.com/2227-9717/9/2/308

2021, Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5399596/

2017, Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2755466/

2009, Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

https://www.frontiersin.org/articles/10.3389/fmolb.2018.00029/full

2018, A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14607

2018, Determinants of dopaminergic neuron loss in Parkinson’s disease

https://journals.sagepub.com/doi/pdf/10.3727/000000006783981990

2006, Progressive Dopamine Neuron Loss in Parkinson’s Disease: The Multiple Hit Hypothesis

https://www.sciencedaily.com/releases/2016/06/160602132424.htm

2016, Declining dopamine may explain why older people take fewer risks

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2908021/

2009, L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

https://journals.lww.com/md-journal/Fulltext/2021/01290/Effects_of_concomitant_use_of_hydrogen_water_and.61.aspx

2021, Effects of concomitant use of H2 water and photobiomodulation on PD, A pilot study